Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy
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چکیده
منابع مشابه
Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy
The most common form of heart failure occurs with normal systolic function and often involves cardiac hypertrophy in the elderly. To clarify the biological mechanisms that drive cardiac hypertrophy in aging, we tested the influence of circulating factors using heterochronic parabiosis, a surgical technique in which joining of animals of different ages leads to a shared circulation. After 4 week...
متن کاملCirculating Growth Differentiation Factor 11/8 Levels Decline With Age.
RATIONALE Growth differentiation factor 11 (GDF11) and GDF8 are members of the transforming growth factor-β superfamily sharing 89% protein sequence homology. We have previously shown that circulating GDF11 levels decrease with age in mice. However, a recent study by Egerman et al reported that GDF11/8 levels increase with age in mouse serum. OBJECTIVE Here, we clarify the direction of change...
متن کاملThrough thick and thin: a circulating growth factor inhibits age-related cardiac hypertrophy.
In an intriguing new study, Loffredo et al report that joining the circulation of old mice with that of young mice reduces age-related cardiac hypertrophy. They also found that the growth factor growth/differentiation factor 11 is a circulating negative regulator of cardiac hypertrophy which suggests that raising growth/differentiation factor 11 levels may be useful to treat cardiac hypertrophy...
متن کاملCorrection to: Circulating Growth Differentiation Factor 11/8 Levels Decline With Age.
In the article by Poggioli et al, “Circulating Growth Differentiation Factor 11/8 Levels Decline with Age,” which published in the January 8, 2016 issue of the journal (Circ Res. 2016;118:29–37. DOI: 10.1161/CIRCRESAHA.115.307521), corrections were needed to the Online Supplement. In Online Table I, we reported values that demonstrate an effect of GDF11/8 on heart weight and body mass. Since th...
متن کاملGrowth differentiation factor 11 (GDF11) - a promising anti-ageing factor - is highly concentrated in platelets.
Recent research suggests that growth differentiation factor 11 (GDF11) could reverse age-related diseases and that its blood concentration decreases with age. This poses plasma from young donors as a therapeutic GDF11 source to treat age-related diseases. In addition, the tissue source of circulating GDF11 remains unknown. We analysed GDF11 levels in paired samples of serum, plasma and platelet...
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ژورنال
عنوان ژورنال: Cell
سال: 2013
ISSN: 0092-8674
DOI: 10.1016/j.cell.2013.04.015